P01-002 – Comparison between different colchicines responders

Results The study group comprised 221 FMF patients (116F, 105M) with a mean age of 12.7±5.3 years. Mean duration of colchicine use was 58.9±45.3 months. Patients were divided into two groups according to their colchicine response; Group I (n=131) included patients with no attacks after colchicine and Group II (n=90) patients with partial or no response to colchicine. Mean age, sex, age at disease onset, age at colchicine onset, family history of FMF, attack frequency, attack duration, clinical features during attacks, duration of colchicine use and M694V carriage were similar between the groups. Final colchicine doses, disease severity scores, acute phase reactant levels (during attack free period) were significantly higher in Group II when compared with those of Group I (p<0.5). Conclusion Colchicine response seems to be related with disease severity scores and acute phase reactant levels (during attack free periods) in FMF patients.